รศ. ดร.นพ. ถกล เจริญศิริสุทธิกุล
ความเชี่ยวชาญ
พยาธิวิทยาคลินิก และ เวชศาสตร์จีโนม
ความชำนาญเฉพาะทาง
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ภาษาพูด
ไทย / อังกฤษประวัติการศึกษา
- 2546: วท.บ. (วิทยาศาสตร์การแพทย์) เกียรตินิยมอันดับ 2 มหาวิทยาลัยมหิดล
- 2550: ปร.ด. (จุลชีววิทยา) มหาวิทยาลัยมหิดล
- 2553: พ.บ. เกียรตินิยมอันดับ 2 มหาวิทยาลัยมหิดล
- 2556: วว. (พยาธิวิทยาคลินิก) แพทยสภา
- 2564: European registered Clinical Laboratory Geneticist, European Board of Medical Genetics
- 2568: ประกาศนียบัตรเวชศาสตร์จีโนมและการให้คำปรึกษาขั้นพื้นฐาน แพทยสภา
ความสนใจ
- Clinical Pathology
- Human Genetics
- Reproductive Genetics
- Epigenetics
ผลงานวิจัย
- Rattanapan Y, Nongwa K, Supanpong C, Satsadeedat C, Sai-Ong T, Kooltheat N, Chareonsirisuthigul T. Downregulation of miR-25-3p and Its Impact on PTAFR and IGF2BP3 Expression in Type 2 Diabetes Mellitus: Implications for Biomarker Discovery and Disease Pathogenesis. J Clin Med Res. 2024 Dec;16(11):536-546. doi: 10.14740/jocmr6099. Epub 2024 Nov 30. PMID: 39635336; PMCID: PMC11614410.
- Thangrua N, Siriboonpiputtana T, Rerkamnuaychoke B, Chareonsirisuthigul T, Korkiatsakul V, Pongphitcha P, Mukda E, Chutipongtanate S, Pakakasama S. Application of Gene Expression Microarray for the Classification of Ph-Like B-Cell Acute Lymphoblastic Leukemia. Int J Lab Hematol. 2025 Feb;47(1):130-139. doi: 10.1111/ijlh.14370. Epub 2024 Oct 2. PMID: 39357526.
- Onsod P, Jaranasaksakul W, Chareonsirisuthigul T, Parinayok R, Rerkamnuaychoke B, Areesirisuk P. Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique. Eur J Obstet Gynecol Reprod Biol. 2024 Jul;298:31-34. doi: 10.1016/j.ejogrb.2024.04.041. Epub 2024 Apr 30. PMID: 38705011.
- Rujirachaivej P, Siriboonpiputtana T, Luangwattananun P, Yuti P, Wutti-In Y, Choomee K, Sujjitjoon J, Chareonsirisuthigul T, Rerkamnuaychoke B, Junking M, Yenchitsomanus PT. Therapeutic potential of third-generation chimeric antigen receptor T cells targeting B cell maturation antigen for treating multiple myeloma. Clin Exp Med. 2024 Apr 29;24(1):90. doi: 10.1007/s10238-024-01347-7. PMID: 38683232; PMCID: PMC11058938.
- Rattanapan Y, Narkpetch S, Chareonsirisuthigul T. Upregulation of miR-20a-5p as the Potential MicroRNA Marker in Red Blood Cell Storage Lesion. Biomed Res Int. 2023 Oct 4;2023:5598590. doi: 10.1155/2023/5598590. PMID: 37829050; PMCID: PMC10567411.
- Parinayok R, Areesirisuk P, Chareonsirisuthigul T, Buchachat W, Rerkamnuaychoke B. Incidence and Types of Fetal Chromosomal Abnormalities in First Trimester of Thai Pregnant Women between Miscarriages and Intrauterine Survivals. Cytogenet Genome Res. 2022;162(7):345-353. doi: 10.1159/000527977. Epub 2023 Mar 1. PMID: 36858029; PMCID: PMC10273899.
- Rattanapan Y, Charong N, Narkpetch S, Chareonsirisuthigul T. Genotyping of the rare Para-Bombay blood group in southern Thailand. Hematol Transfus Cell Ther. 2023 Oct-Dec;45(4):449-455. doi: 10.1016/j.htct.2022.08.004. Epub 2022 Oct 9. PMID: 36241527; PMCID: PMC10627842.
- Rojanaporn D, Chitphuk S, Iemwimangsa N, Chareonsirisuthigul T, Saengwimol D, Aroonroch R, Anurathathapan U, Hongeng S, Kaewkhaw R. Germline RB1 Mutation in Retinoblastoma Patients: Detection Methods and Implication in Tumor Focality. Transl Vis Sci Technol. 2022 Sep 1;11(9):30. doi: 10.1167/tvst.11.9.30. PMID: 36173648; PMCID: PMC9527333.
- Trachoo O, Yingchoncharoen T, Ngernsritrakul T, Iemwimangsa N, Panthan B, Klumsathian S, Srisukh S, Mukdadilok A, Phusanti S, Charoenyingwattana A, Chareonsirisuthigul T, Chantratita W, Tangcharoen T. Genomic findings of hypertrophic and dilated cardiomyopathy characterized in a Thai clinical genetics service. PLoS One. 2022 Sep 27;17(9):e0267770. doi: 10.1371/journal.pone.0267770. PMID: 36166435; PMCID: PMC9514623.
- Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T, Chareonsirisuthigul T, Phornsarayuth P, Klinkulab N, Jinawath N, Chiangjong W, Anurathapan U, Pattanapanyasat K, Hongeng S, Chutipongtanate S. Extracellular Vesicle-Based Method for Detecting MYCN Amplification Status of Pediatric Neuroblastoma. Cancers (Basel). 2022 May 26;14(11):2627. doi: 10.3390/cancers14112627. PMID: 35681607; PMCID: PMC9179557.
- Prapasrat C, Onsod P, Korkiatsakul V, Rerkamnuaychoke B, Wattanasirichaigoon D, Chareonsirisuthigul T. The Utilization of MS-MLPA as the First-Line Test for the Diagnosis of Prader-Willi Syndrome in Thai Patients. J Pediatr Genet. 2022 Jan 7;12(4):273-279. doi: 10.1055/s-0041-1741008. PMID: 38162164; PMCID: PMC10756717.
- Traisrisilp K, Sirikunalai P, Sirilert S, Chareonsirisuthigul T, Tongsong T. Cardiac rhabdomyoma as a possible new prenatal sonographic feature of Prader-Willi syndrome. J Obstet Gynaecol Res. 2022 Jan;48(1):239-243. doi: 10.1111/jog.15073. Epub 2021 Oct 16. PMID: 34655138.
- Kamseng P, Siriboonpiputtana T, Puavilai T, Chuncharunee S, Paisooksantivatana K, Chareonsirisuthigul T, Junking M, Chiraphapphaiboon W, Yenchitsomanus PT, Rerkamnuaychoke B. Targeting UCHL1 Induces Cell Cycle Arrest in High-Risk Multiple Myeloma with t(4;14). Pathol Oncol Res. 2021 Mar 31;27:606567. doi: 10.3389/pore.2021.606567. PMID: 34257568; PMCID: PMC8262241.
- Rattanapan Y, Korkiatsakul V, Kongruang A, Siriboonpiputtana T, Rerkamnuaychoke B, Chareonsirisuthigul T. High Expression of miR-483-5p Predicts Chemotherapy Resistance in Epithelial Ovarian Cancer. Microrna. 2021;10(1):51-57. doi: 10.2174/2211536610666210412155206. PMID: 33845755.
- Rojnueangit K, Khetkham T, Onsod P, Chareonsirisuthigul T. Clinical Features to Predict 22q11.2 Deletion Syndrome Proven by Molecular Genetic Testing. J Pediatr Genet. 2020 Oct 1;11(1):22-27. doi: 10.1055/s-0040-1718386. PMID: 35186386; PMCID: PMC8847066.
- Tangshewinsirikul C, Dulyaphat W, Tim-Aroon T, Parinayok R, Chareonsirisuthigul T, Korkiatsakul V, Waisayarat J, Sirisreetreerux P, Tingthanatikul Y, Wattanasirichaigoon D. Klinefelter Syndrome Mosaicism 46,XX/47,XXY: A New Case and Literature Review. J Pediatr Genet. 2020 Dec;9(4):221-226. doi: 10.1055/s-0040-1713002. Epub 2020 Jun 17. PMID: 32733741; PMCID: PMC7384885.
- Rattanapan Y, Korkiatsakul V, Kongruang A, Siriboonpiputtana T, Rerkamnuaychoke B, Chareonsirisuthigul T. MicroRNA Expression Profiling of Epithelial Ovarian Cancer Identifies New Markers of Tumor Subtype. Microrna. 2020;9(4):289-294. doi: 10.2174/2211536609666200722125737. PMID: 32703147.
- Dokrungkoon T, Onsod P, Areesirisuk P, Rerkamnuaychoke B, Vanikieti K, Chareonsirisuthigul T. Performance of the MLPA technique for detecting common mutations in Leber hereditary optic neuropathy. Mitochondrial DNA A DNA Mapp Seq Anal. 2019 Dec;30(8):819-824. doi: 10.1080/24701394.2019.1670819. PMID: 31566038.
- Rojanaporn D, Boontawon T, Chareonsirisuthigul T, Thanapanpanich O, Attaseth T, Saengwimol D, Anurathapan U, Sujirakul T, Kaewkhaw R, Hongeng S. Spectrum of germline RB1 mutations and clinical manifestations in retinoblastoma patients from Thailand. Mol Vis. 2018 Dec 9;24:778-788. PMID: 30636860; PMCID: PMC6300611.
- Rujirachaivej P, Siriboonpiputtana T, Rerkamnuaychoke B, Magmuang S, Chareonsirisuthigul T, Boonsakan P, Petvises S, Sirirat T, Niparuck P, Chuncharunee S. The Frequency of SF3B1 Mutations in Thai Patients with Myelodysplastic Syndrome. Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1825-1831. doi: 10.22034/APJCP.2018.19.7.1825. PMID: 30049194; PMCID: PMC6165635.
- Rattanapan Y, Korkiatsakul V, Kongruang A, Chareonsirisuthigul T, Rerkamnuaychoke B, Wongkularb A, Wilailak S. EGFL7 and RASSF1 promoter hypermethylation in epithelial ovarian cancer. Cancer Genet. 2018 Aug;224-225:37-40. doi: 10.1016/j.cancergen.2018.04.117. PMID: 29778234.
- Sommaluan S, Rerkamnuaychoke B, Pauwilai T, Chancharunee S, Onsod P, Pornsarayuth P, Chareonsirisuthigul T, Tammachote R, Siriboonpiputtana T. The Utilization of Karyotyping, iFISH, and MLPA for the Detection of Recurrence Genetic Aberrations in Multiple Myeloma. Asian Pac J Cancer Prev. 2017 Nov;18(11):3135-3142. doi: 10.22034/APJCP.2017.18.11.3135. PMID: 29172291; PMCID: PMC5773803.
- Limsuwanachot N, Rerkamnuaychoke B, Chuncharunee S, Pauwilai T, Singdong R, Rujirachaivej P, Chareonsirisuthigul T, Siriboonpiputtana T. Clinical and hematological relevance of JAK2 V617F and CALR mutations in BCR-ABL-negative ET patients. Hematology. 2017 Dec;22(10):599-606. doi: 10.1080/10245332.2017.1312736. PMID: 28406068.
- Sirirat T, Chuncharunee S, Nipaluk P, Siriboonpiputtana T, Chareonsirisuthigul T, Limsuwannachot N, Rerkamnuaychoke B. Mutation Analysis of Isocitrate Dehydrogenase (IDH1/2) and DNA Methyltransferase 3A (DNMT3A) in Thai Patients with Newly Diagnosed Acute Myeloid Leukemia. Asian Pac J Cancer Prev. 2017 Feb 1;18(2):413-420. doi: 10.22034/APJCP.2017.18.2.413. PMID: 28345823; PMCID: PMC5454736.
- Singdong R, Siriboonpiputtana T, Chareonsirisuthigul T, Kongruang A, Limsuwanachot N, Sirirat T, Chuncharunee S, Rerkamnuaychoke B. Characterization and Prognosis Significance of JAK2 (V617F), MPL, and CALR Mutations in Philadelphia-Negative Myeloproliferative Neoplasms. Asian Pac J Cancer Prev. 2016 Oct 1;17(10):4647-4653. doi: 10.22034/apjcp.2016.17.10.4647. PMID: 27892678; PMCID: PMC5454611.
- Limsuwanachot N, Siriboonpiputtana T, Karntisawiwat K, Chareonsirisuthigul T, Chuncharunee S, Rerkamnuaychoke B. Multiplex RT-PCR Assay for Detection of Common Fusion Transcripts in Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia Cases. Asian Pac J Cancer Prev. 2016;17(2):677-684. doi: 10.7314/apjcp.2016.17.2.677. PMID: 26925663.
- Chareonsirisuthigul T, Worawichawong S, Parinayok R, Promsonthi P, Rerkamnuaychoke B. Intrauterine growth retardation fetus with trisomy 16 mosaicism. Case Rep Genet. 2014;2014:739513. doi: 10.1155/2014/739513. Epub 2014 May 14. PMID: 24955263; PMCID: PMC4052622.
- Chareonsirisuthigul T, Khositnithikul R, Intaramat A, Inkomlue R, Sriwanichrak K, Piromsontikorn S, Kitiwanwanich S, Lowhnoo T, Yingyong W, Chaiprasert A, Banyong R, Ratanabanangkoon K, Brandhorst TT, Krajaejun T. Performance comparison of immunodiffusion, enzyme-linked immunosorbent assay, immunochromatography and hemagglutination for serodiagnosis of human pythiosis. Diagn Microbiol Infect Dis. 2013 May;76(1):42-45. doi: 10.1016/j.diagmicrobio.2013.02.025. PMID: 23537786.
- Ubol S, Chareonsirisuthigul T, Kasisith J, Klungthong C. Clinical isolates of dengue virus with distinctive susceptibility to nitric oxide radical induce differential gene responses in THP-1 cells. Virology. 2008 Jul 5;376(2):290-296. doi: 10.1016/j.virol.2008.03.030. PMID: 18455750.
- Chareonsirisuthigul T, Kalayanarooj S, Ubol S. Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells. J Gen Virol. 2007 Feb;88(Pt2):365-375. doi: 10.1099/vir.0.82537-0. PMID: 17251552.





