Exposure to ultraviolet (UV) radiation is one of the major factors that causes erythema, sunburn, and skin cancer. Moreover, the sun destroys hyaluronic acid, collagen, and elastin and finally makes our skin aging.
Hyaluronic acid (HA) is a polysaccharide found in the extracellular connective tissues accumulated between the collagen, its retention moisture properties make our skin youthful and smooth. Hyaluronic acid also helps to protect the skin from UV damage. This is because it helps to form a barrier on the skin that can block UV rays from penetrating the skin. Unfortunately, scientific studies reveal hyaluronic and collagen can be degraded after exposure to the sun.
Nowadays, there are many options to reverse the effect of sun damage such as retinoid cream, chemical peeling, and pigmented lightening products, but outturns are slow-growing. This links to the replacement of synthetic hyaluronic into the skin to repair those damages. The biocompatibility and viscoelasticity properties of this hyaluronic polymer become an important component of major pharmaceutical, biomedical, and cosmetic products with high commercial value worldwide.
Another popular repair method is to use polynucleotide-based products to promote dermal rejuvenation and revitalization. Polynucleotides are natural, highly purified DNA molecules extracted from wild salmon DNA or trout gonads which are hypoallergenic to human skin. Polynucleotide-containing products improve skin well‐being and sustain steady self‐repair. The final outcome is more natural and in‐depth tissue regeneration and a healthier look of the skin. Clinical trials on 143 patients demonstrated an improvement in skin elasticity and hydration, together with high levels of patient and physician satisfaction.
What are the ingredients in Belotero Revive?
Belotero Revive helps target the signs of sun damage which include dehydrated skin, loss of elasticity and firmness, presence of fine lines, and uneven pigmentation and texture. Belotero Revive combines 2 active ingredients – Hyaluronic acid and Glycerol.
What are the ingredients of Rejuran?
Rejuran is a concentrated injectable polynucleotide that has an antioxidant action, protection, and reduction of cell damage caused by UV radiation and influences cellular growth. Expert consensus illustrates the value of intradermal polynucleotide as biostimulatory boosters for priming and revitalization of face and body skin.
- Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):922-928. doi:10.1111/jocd.13679
- Shaheen, A.E., Gebreel, H.M., Moussa, L.A. et al. Photoprotection Against UV-Induced Skin Damage Using Hyaluronic Acid Produced by Lactiplantibacillus plantarum and Enterococcus durans. Curr Microbiol 80, 262 (2023). https://doi.org/10.1007/s00284-023-03377-y
- Averbeck M, Gebhardt CA, Voigt S, Beilharz S, Anderegg U, Termeer CC, Sleeman JP, Simon JC. Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation. J Invest Dermatol. 2007 Mar;127(3):687-97. doi: 10.1038/sj.jid.5700614. Epub 2006 Nov 2. PMID: 17082783.